Prostaglandin F2α Stimulates Hypertrophic Growth of Cultured Neonatal Rat Ventricular Myocytes
نویسندگان
چکیده
منابع مشابه
Tyrosine kinase and c-Jun NH2-terminal kinase mediate hypertrophic responses to prostaglandin F2alpha in cultured neonatal rat ventricular myocytes.
Myocardial infarction results in focal areas of ischemia, hypoxia, necrosis, and decreased contractile function. To compensate for loss of contractile function, remaining viable myocytes undergo hypertrophic growth. Prostaglandin F2alpha (PGF2alpha), which is released from cells of the myocardium during periods of stress such as hypoxia or ischemia/reperfusion, has recently been shown to stimul...
متن کاملCo-culture of rat neonatal ventricular myocytes and GFP-labeled feline c-Kit cells: Neonatal rat ventricular myocytes
BrdU infusion into normal cats: Osmotic pumps (ALZET) were filled with 50mg/mL BrdU dissolved in 50% DMSO/50% ddH2O filtered through a sterile 0.22μm filter. Pumps were then incubated in sterile saline at 37 °C overnight prior to insertion. The pumps were surgically inserted subcutaneously just caudal to the scapulae per the protocol approved by IACUC at Temple University. The number of pumps w...
متن کاملUnusual localization and translocation of TRPV4 protein in cultured ventricular myocytes of the neonatal rat
TRPV4 protein forms a Ca2+-permeable channel that is sensitive to osmotic and mechanical stimuli and responds to warm temperatures, and expresses widely in various kinds of tissues. As for cardiac myocytes, TRPV4 has been detected only at the mRNA level and there were few reports about subcellular localization of the protein. The purpose of the present study was to investigate the expression pr...
متن کاملRole of protein kinase C-e in hypertrophy of cultured neonatal rat ventricular myocytes
Strait, James B., III, Jody L. Martin, Allison Bayer, Ruben Mestril, Diane M. Eble, and Allen M. Samarel. Role of protein kinase C-e in hypertrophy of cultured neonatal rat ventricular myocytes. Am J Physiol Heart Circ Physiol 280: H756–H766, 2001.—Using adenovirus (Adv)-mediated overexpression of constitutively active (ca) and dominantnegative (dn) mutants, we examined whether protein kinase C...
متن کاملGap junctional remodeling by hypoxia in cultured neonatal rat ventricular myocytes.
OBJECTIVES Altered gap junctional coupling of ventricular myocytes plays an important role in arrhythmogenesis in ischemic heart disease. Since hypoxia is a major component of ischemia, we tested the hypothesis that hypoxia causes gap junctional remodeling accompanied by conduction disturbances. METHODS Cultured neonatal rat ventricular myocytes were exposed to hypoxia (1% O(2)) for 15 min to...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1996
ISSN: 0021-9258
DOI: 10.1074/jbc.271.2.1179